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Article
Nature Immunology  4, 269 - 273 (2003)
Published online: 27 January 2003; | doi:10.1038/ni888

Angiogenins: a new class of microbicidal proteins involved in innate immunity

Lora V. Hooper, Thaddeus S. Stappenbeck, Chieu V. Hong & Jeffrey I. Gordon

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Correspondence should be addressed to Jeffrey I. Gordon jgordon@molecool.wustl.edu
Although angiogenins have been implicated in tumor-associated angiogenesis, their normal physiologic function remains unclear. We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against intestinal microbes. Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal commensal bacteria influence gut microbial ecology and shape innate immunity. Furthermore, mouse Ang1 and human angiogenin, circulating proteins induced during inflammation, exhibit microbicidal activity against systemic bacterial and fungal pathogens, suggesting that they contribute to systemic responses to infection. These results establish angiogenins as a family of endogenous antimicrobial proteins.

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REFERENCE
Immunological Cytotoxic Factors
Nature Encyclopaedia of Life Sciences

NEWS AND VIEWS
Angiogenin: an antimicrobial ribonuclease
Nature Immunology News and Views (01 Mar 2003)
Research News
Nature Medicine News and Views (01 Mar 2003)

RESEARCH
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
Nature Immunology Article (01 Aug 2000)

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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