Nature Immunology
4, 208 - 209 (2003)
doi:10.1038/ni0303-208
Il2 transcription unleashed by active DNA demethylationAdrian Bird
Wellcome Trust Centre for Cell Biology, Kings Buildings, Edinburgh University, Edinburgh EH9 3JR, UK. a.bird@ed.ac.uk
The idea that genes are transcriptionally activated by rapid CpG demethylation has been controversial. New data provides the most compelling evidence yet, implicating a mysterious enzyme activity that can actively demethylate DNA.
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