Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)- independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN- promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3−dependent production of IFN- is mediated mainly by TICAM-1. This TICAM-1−dependent pathway may have a role in other TLR−IFN- pathways, which form part of the MyD88-independent cellular immune response.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
induction
independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-
B activation
