Kohki Kawane1, Hidehiro Fukuyama1, 6, Hideyuki Yoshida1, Hiroko Nagase1, Yoshiyuki Ohsawa2, Yasuo Uchiyama2, Kazuhisa Okada3, Tetsuya Iida3
& Shigekazu Nagata1, 4, 51
Department of Genetics, Osaka University Medical School, Osaka 565-0871, Japan
2
Departments of Cell Biology and Neuroscience, Osaka University Medical School, Osaka 565-0871, Japan
3
Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
4
Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan
5
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka 565-0871, Japan
6
Present address: Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA.
Correspondence should be addressed to Shigekazu Nagata nagata@genetic.med.osaka-u.ac.jp
gene was strongly up-regulated in the thymus of DNase II-/-CAD-/- embryos, suggesting that when the DNA of apoptotic cells is left undigested, it can activate innate immunity leading to defects in thymic development.
