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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  4, 105 - 106 (2003) doi:10.1038/ni0203-105 Toll signaling: the TIReless quest for specificity Jean-Luc Imler & Jules A. Hoffmann Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67000 Strasbourg, France J.Hoffmann@ibmc.u-strasbg.fr and JL.Imler@ibmc.u-strasbg.fr The identification of a third TIR domain adaptor molecule involved in TLR3-mediated interferon- induction helps explain TLR signaling specificity. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS Dendritic-cell control of pathogen-driven T-cell polarization Nature Reviews Immunology Review (01 Dec 2003)  See all 15 matches for Reviews NEWS AND VIEWS Adjuvants and their signaling pathways: beyond TLRs Nature Immunology News and Views (01 Dec 2003) Linking Toll-like receptors to IFN-/ expression Nature Immunology News and Views (01 May 2003)  See all 13 matches for News And Views RESEARCH TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway Nature Immunology Article (01 Nov 2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon- induction Nature Immunology Article (01 Feb 2003)  See all 42 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... Optimizing Sub-cellular Localization Tags Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... More Challenges Powered by: nature jobs Electrophysiologist TCG Lifesciences Ltd Kolkata India Professor / Associate Professor (Pharmaceutics / Pharmaceutical Analysis&quality Control) Alliance Institute of Advanced Pharmacy and Health Sciences Hyderabad 500038 India More science jobs Post a job for free Figures & Tables See also: Article by Oshiumi et al. Export citation Search buyers guide:   ADVERTISEMENT

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