Jean-Marc Reichhart is at the Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France. jm.reichhart@ibmc.u-strasbg.fr
The Toll-like receptor (TLR) family targets pathogen-derived molecules in regions unlikely to change under selection pressures. For TLR5, which recognizes the protein flagellin, the function of the targeting motif is key.
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