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Nature Immunology  4, 1052 - 1054 (2003)
doi:10.1038/ni1103-1052

LFA-1: more than just T cell Velcro

Yoji Shimizu

Yoji Shimizu is at the Department of Laboratory Medicine and Pathology, Center for Immunology and Cancer Center, University of Minnesota Medical School, MMC 334/31, Church St. SE, Minneapolis, MN 55455. shimi002@umn.edu

The LFA-1 integrin is known to mediate adhesion between T cells and antigen-presenting cells. New evidence, however, is provided for its role in transmitting signals that promote T cell activation and differentiation.

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REFERENCE
Integrins: Signalling and Disease
Nature Encyclopaedia of Life Sciences

REVIEWS
Membranes as messengers in T cell adhesion signaling
Nature Immunology Review (01 Apr 2004)
 See all 2 matches for Reviews

NEWS AND VIEWS
Research notes
Nature Immunology News and Views (01 Mar 2004)
PKC-beta(I): the whole ignition system or just a sparkplug for T cell migration?
Nature Immunology News and Views (01 Jun 2001)

RESEARCH
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
Nature Immunology Article (01 Nov 2003)
Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1
The EMBO Journal Article (01 Jun 2000)
 See all 6 matches for Research

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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