1
Margarita Del Val is at the Unidad de Immunología Viral, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Madrid, Spain
2
Jonathan W. Yewdell is at the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. jyewdell@nih.gov
Patients with type 2 Hermansky-Pudlak syndrome are immunodeficient. Mutations in AP-3 that prevent movement of lytic granules along microtubules in CD8+ T cells help explain these patients' susceptibility to infection.
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