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Article
Nature Immunology  4, 1009 - 1015 (2003)
Published online: 21 September 2003; | doi:10.1038/ni978

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

Agnes Le Bon1, 5, Nathalie Etchart1, 4, 5, Cornelia Rossmann2, Miranda Ashton1, Sam Hou1, Dirk Gewert3, Persephone Borrow1 & David F Tough1

1  The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, England.

2  Acambis, Peterhouse Technology Park, 100 Fulbourn Road, Cambridge CB1 9PT, England.

3  BioLauncher, 50 Gilbert Road, Cambridge CB4 3PE, England.

4  Present address: Institut National de la Santé et de la Recherche Médicale U404, IFR 74-CERVI, 21 Avenue Tony Garnier, 69365 LYON Cedex 07, France.

5  These authors contributed equally to this work.

Correspondence should be addressed to David F Tough david.tough@jenner.ac.uk
CD8+ T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as cross-priming. To initiate cross-priming, APCs must both capture extracellular antigen and receive specific activation signals. We have investigated the nature of APC activation signals associated with virus infection that stimulate cross-priming. We show that infection with lymphocytic choriomeningitis virus induces cross-priming by a mechanism dependent on type I interferon (IFN-alpha/beta). Activation of cross-priming by IFN-alpha/beta was independent of CD4+ T cell help or interaction of CD40 and CD40 ligand, and involved direct stimulation of dendritic cells. These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections.

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REFERENCE
Dendritic Cells (T Lymphocyte Stimulating)
Nature Encyclopaedia of Life Sciences

REVIEWS
CROSS-PRESENTATION IN VIRAL IMMUNITY AND SELF-TOLERANCE
Nature Reviews Immunology Review Article (01 Nov 2001)
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NEWS AND VIEWS
Type I interferons promote cross-priming: more functions for old cytokines
Nature Immunology News and Views (01 Oct 2003)
Blood lines
Nature Immunology News and Views (01 Aug 2002)
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RESEARCH
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
Nature Immunology Article (01 Mar 2002)
 See all 18 matches for Research

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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