Nature Immunology4, 982 - 990 (2003)
Published online: 31 August 2003; | doi:10.1038/ni970
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Andrew M Tager1, 2, 4, Shannon K Bromley1, 4, Benjamin D Medoff1, 2, Sabina A Islam1, Scott D Bercury1, Erik B Friedrich1, Andrew D Carafone1, Robert E Gerszten1, 3
& Andrew D Luster1
1
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
2
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
3
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein−coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (TH1) and TH2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.
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