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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Article Nature Immunology  4, 25 - 30 (2002) Published online: 16 December 2002; | doi:10.1038/ni874 Essential role of Id2 in negative regulation of IgE class switching Manabu Sugai1, Hiroyuki Gonda1, 2, Takashi Kusunoki3, Tomoya Katakai1, Yoshifumi Yokota4 & Akira Shimizu1, 2 1  Center for Molecular Biology and Genetics, Kyoto University, Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. 2  Translational Research Center, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. 3  Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. 4  Department of Biochemistry, Fukui Medical University, 23-3 Shimoaizuki, Matsuoka, Fukui 910-1193, Japan. Correspondence should be addressed to Akira Shimizu shimizu@virus.kyoto-u.ac.jpSerum concentrations of immunoglobulin E (IgE) in normal circumstances are kept much lower than those of other Ig isotypes to avoid allergic reactions. B cells lacking Id2 have increased E2A activity, which leads to specific enhancement of germline transcription of the immunoglobulin locus. As a consequence, Id2-deficient B cells undergo class switch recombination (CSR) to IgE at a much higher frequency than wild-type B cells. In contrast, Id2 is induced in wild-type B cells by transforming growth factor-1 (TGF-1) and suppresses IgE CSR. Our results provide evidence for the inhibitory and selective role of Id2 in IgE CSR in response to TGF-1. Id2 might act as molecular safeguard to suppress IgE CSR to prevent serious complications such as allergic hypersensitivity during the normal course of immune responses. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS The regulation of immunoglobulin E class-switch recombination Nature Reviews Immunology Review (01 Sep 2003) The regulation and function of the Id proteins in lymphocyte development Oncogene Review Article (17 Jan 2002)  See all 4 matches for Reviews NEWS AND VIEWS Yin outwits Yang at the IgE locus Nature Immunology News and Views (01 Jan 2003) RESEARCH E-proteins directly regulate expression of activation-induced deaminase in mature B cells Nature Immunology Article (01 Jun 2003) Transcriptional profiling identifies Id2 function in dendritic cell development Nature Immunology Article (01 Apr 2003)  See all 8 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... More Challenges Powered by: nature jobs Executive Director & Deans Translational Health Science and Technology Institute (THSTI); C / o National Institute of Immunology Delhi 110067 India Head of Analytical R&D Syngene International Limited Bangalore 560 099 India More science jobs Post a job for free Figures & Tables See also: News and Views by Maizels Export citation Search buyers guide:   ADVERTISEMENT

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