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Nature Immunology  4, 7 - 8 (2003)
doi:10.1038/ni0103-7

Yin outwits Yang at the IgE locus

Nancy Maizels

Departments of Immunology and Biochemistry, University of Washington Medical School, 1959 NE Pacific St., HSB H474A, Seattle, WA 98195-7650, USA. maizels@u.washington.edu

Serum IgE concentrations are kept low to avoid potential allergic complications. New data show how Id2 suppresses class switching to the epsilon isotype and reduces IgE expression.

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REVIEWS
The regulation of immunoglobulin E class-switch recombination
Nature Reviews Immunology Review (01 Sep 2003)

RESEARCH
Essential role of Id2 in negative regulation of IgE class switching
Nature Immunology Article (01 Jan 2003)

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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