Nature Immunology
3, 852 - 858 (2002)
Published online: 12 August 2002; | doi:10.1038/ni832
Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivoChang-you Wu1, Joanna R. Kirman1, Masashi J. Rotte1, Dylan F. Davey1, Steve P. Perfetto2, Elizabeth G. Rhee1, Brenda L. Freidag1, Brenna J. Hill3, Daniel C. Douek3
& Robert A. Seder11
Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3005, USA. 2
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3005, USA. 3
Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3005, USA.
Correspondence should be addressed to Robert A. Seder rseder@mail.nih.govWe studied here the long-term maintenance of distinct populations of T helper type 1 (TH1)-lineage cells in vivo and found that effector TH1 cells, defined by their secretion of interferon- (IFN-), are short-lived and do not efficiently develop into long-term memory TH1 cells. In contrast, a population of activated TH1-lineage cells that did not secrete IFN- after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN- upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-−producing to resting memory cells, is relatively limited in vivo and support a revised model for TH1 memory differentiation.
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