Department of Dermatology, Friedrich-Wilhelms University of Bonn, Sigmund-Freud-Str.25, 53105 Bonn, Germany. thomas.bieber@ukb.uni-bonn.de
IgE-FcRI complex formation represents a critical step in the initiation of allergic responses. Conformational changes involving the C2 domain may underlie the persistent activation of FcRI-bearing cells.