Nature Immunology
3, 508 - 510 (2002)
doi:10.1038/ni0602-508
Trypsin, for the defenseMichael Zasloff
Georgetown University, Medical Center, Med-Dent
Building 103 NW, 3900 Reservoir Road NW,
Washington, DC 20007, USA.
maz5@georgetown.edu
The  -defensins from Paneth cells in intestinal crypts need
processing to be fully functional. Unlike for mice, the cleaving enzyme for
human HD5 turns out to be trypsin.
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