Regulation of THI differentiation − controlling the
controllers
John J. O'Shea
& William E. Paul
Molecular Immunology and Inflammation Branch,
National Institute of Arthritis, Musculoskeletal and Skin Disease and the
Laboratory of Immunology, National Institute of Allergy and Infectious Disease,
National Institutes of Health, Bethesda, MD
20892, USA. osheajo@mail.nih.gov
Although cytokines and STATs are accepted as being integral to
TH1 differentiation, T-bet had emerged as a possible master control
switch. Fresh data forces a reexamination of the factors that control
TH cell development.
