Revival of the autoantibody model in rheumatoid arthritis
Toshio Hirano
Department of Molecular Oncology, Osaka University Graduate School of Medicine. Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Osaka 565-0871, Japan. hirano@molonc.med.osaka-u.ac.jp
New evidence revives the old idea that B cells are the principal effectors in rheumatoid arthritis: autoantibodies against a ubiquitous antigen cause joint-specific disease. The resolution of these conflicting hypotheses resides in the joint itself. "(On-Ko-Chi-Shin) the new idea resides within the old."
(On-Ko-Chi-Shin) the new idea resides within the old."
