Nature Immunology
3, 212 - 213 (2002)
doi:10.1038/ni0302-212
Antigen receptors rap to integrin receptorsRobert T. Abraham
Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. abraham@burnham.org
The biochemical events that mediate inside-out signaling to  1 and 2 integrin receptors after TCR ligation are poorly understood. Using a transgenic mouse model, investigators have implicated an unexpected candidate, Rap1, as a key mediator of inside-out signaling in activated T cells.
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