Nature Immunology
3, 210 - 211 (2002)
doi:10.1038/ni0302-210
Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytesStaffan Normark1, 3, Barbara Albiger2
& Ann-Beth Jonsson11
Microbiology and Tumor biology Center, Karolinska Institute, Stockholm, Sweden. 2
Swedish Institute for Infectious Disease Control, Stockholm Sweden. 3
Staffan.Normark@stratresearch.se
Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4+ T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.
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