Nature Immunology
3, 1163 - 1168 (2002)
Published online: 4 November 2002; | doi:10.1038/ni851
CD1-dependent dendritic cell instructionMichael S. Vincent1, David S. Leslie1, Jenny E. Gumperz1, Xiaowei Xiong1, Ethan P. Grant2
& Michael B. Brenner11
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA. 2
Present address: Millennium Pharmaceuticals Inc., 45 Sidney Street, Cambridge, MA 02139, USA.
Correspondence should be addressed to Michael B. Brenner mbrenner@rics.bwh.harvard.eduBoth microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity, when foreign antigen−specific T cells are rare. We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens. T cell recognition of all four CD1 isoforms can trigger DC maturation, but their distinct mechanisms of costimulation lead to profound differences in concomitant interleukin 12 p70 production. Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity.
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