CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.
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Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications
Experimental & Molecular Medicine Open Access 07 January 2019
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Finger, E., Bluestone, J. When ligand becomes receptor—tolerance via B7 signaling on DCs. Nat Immunol 3, 1056–1057 (2002). https://doi.org/10.1038/ni1102-1056
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DOI: https://doi.org/10.1038/ni1102-1056
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