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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  3, 1056 - 1057 (2002) doi:10.1038/ni1102-1056 When ligand becomes receptor—tolerance via B7 signaling on DCs Erik B. Finger1, 2 & Jeffrey A. Bluestone1 1  UCSF Diabetes Center, UCSF School of Medicine, San Francisco, CA 94143, USA. 2  Present address: Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA. Correspondence should be addressed to Jeffrey A. Bluestone jbluest@diabetes.ucsf.eduCTLA-4−Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Optimizing Sub-cellular Localization Tags Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... More Challenges Powered by: nature jobs Materials Engineer Praj Matrix - Praj Industries Ltd Pune, Maharashtra Pune-411021 India Postdoctoral Fellow in Immunology The Scripps Research Institute N Torrey Pines Rd, San Diego, CA, USA More science jobs Post a job for free Figures & Tables See also: Article by Grohmann et al. Export citation Search buyers guide:   ADVERTISEMENT

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