Nature Immunology
3, 896 - 898 (2002)
doi:10.1038/ni1002-896
Two faces of caspase-8Bryan C. Barnhart
& Marcus E. Peter
The Ben May Institute for Cancer Research, University of Chicago, 924 E. 57th St., Chicago, IL 60637, USA.
Correspondence should be addressed to Marcus E. Peter MPeter@ben-may.bsd.uchicago.eduA deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
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