Location, location, location: the cell biology of immunoglobulin allelic control
David G. T. Hesslein, Patrick E. Fields
& David G. Schatz
Department of Cell Biology, Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. (david.schatz@yale.edu)
Individual lymphocytes express antigen receptors of a singular specificity. How this process, known as allelic exclusion, is established and maintained is unknown. Differences in subnuclear localization appear to contribute to enforcement of monoallelic receptor expression.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
