"Decisions, decisions ...": -catenin−mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells
Li Wu
& Andreas Strasser
The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Australia, Melbourne, Australia. (strasser@wehi.edu.au)
Successful passage through several developmental checkpoints determines whether thymocytes survive, proliferate or differentiate. New data show that Wnt-frizzled−induced activation of TCF-1 or Lef-1, via their coactivator -catenin, is critical during TCRB and TCRA gene rearrangement in thymocytes.
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-catenin−mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells
-catenin, is critical during TCRB and TCRA gene rearrangement in thymocytes.
T lymphocytes
