Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity
Peter E. Lipsky
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. (lipskyp@mail.nih.gov)
B cells can regulate many aspects of immune reactivity, as well as differentiate into antibody-producing cells. In SLE, a systemic autoimmune disease, recent research suggests enhanced B cell function is the defining pathogenic event.
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