The mucosal milieu creates tolerogenic dendritic cells and TR1 and TH3 regulatory cells
Howard L. Weiner
Harvard Medical School, Center for Neurologic Diseases, Brigham and Women's Hospital, 77 Ave Louis Pasteur, HIM 720, Boston, MA 02115, USA. (weiner@cnd.bwh.harvard.edu)
Certain types of regulatory T cells are preferentially induced at mucosal surfaces to maintain tolerance. However, the mechanisms involved in their induction are unclear. New evidence suggests DCs orchestrate this mucosal tolerogenic immune response.
