SAP: natural inhibitor or grand SLAM of T cell activation?
Kim E. Nichols, Gary A. Koretzky
& Carl H. June
Abramson Family Cancer Research Institute, University of Pennsylvania, and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. (cjune@mail.med.upenn.edu)
Identification of SH2D1A as the defective gene in X-linked lymphoproliferative syndrome highlighted the importance of SAP in the regulation of T cell activation. New data suggest an alternative explanation for how SAP controls signaling.
