ICOS costimulation: it's not just for TH2 cells anymore
Anne I. Sperling1
& Jeffrey A. Bluestone2
1
Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. (asperlin@medicine.bsd.uchicago.edu)
2
A. W. and Mary Margaret Clausen Professor, UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. (jbluest@diabetes.ucsf.edu)
A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.
