 | About the cover
June 2001 - Vol 2 No 6
Nature Immunology 2 (2001)
| | |    | The binding of LFA-1 on a T cell's surface is a critical step for intravascular adhesion and cell migration. Volkov et al. report that, in the T cell's uropod, LFA-1 activates the PKC- (I) (green) pathway to trigger the polymer-ization of tubulin (red) and there-by initiate the migratory capacity of the cells. Blue, nuclei; yellow-orange, colocalization of PKC-(I) and tubulin. Fluorescent image taken by Y. Volkov with an 100x oil immersion lens on a Nikon TE300 microscope and Photometrics-cooled CCD camera.
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