DNA polymerases in immunity: profiting from errors
Ursula Storb
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. (stor@midway.uchicago.edu)
Multiple error-prone DNA polymerase appear to contribute to immunoglobulin somatic hypermutation. Genetic and biochemical data now indicate that DNA polymerase may be responsible for the generation of some of the strand-biased hotspot A mutations in the immunoglobulin loci.
may be responsible for the generation of some of the strand-biased hotspot A mutations in the immunoglobulin loci.
