Multifaceted roles of MHC class I and MHC class I−like molecules in T cell activation
Sophie Ugolini1
& Eric Vivier2
1
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Sophia-Antipolis, France.
2
Institut Universitaire de France and Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Univ. Med., Campus de Luminy, Marseille, France.vivier@ciml.univ-mrs.fr
In addition to the TCR and classical MHC class I, MHC class 1−like molecules can interact with a variety of receptors that play a role in T cell activation. Engagement of NKG2D on CMV-specific CD8+ cells by MIC was found to provide them with a costimulatory signal and augment their cytotoxic response.
CD8+ cells by MIC was found to provide them with a costimulatory signal and augment their cytotoxic response.
