Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Univ. Med., Case 906, 13288 Marseille Cedex 9, France.bernardm@ciml.univ-mrs.fr
A minimal half-life of the TCR-pMHC interaction is required for complete T cell signaling (the kinetic proof reading model). In an extension to this model it is clear that the dwell time or half-life of TCR-pMHC interaction is also critical for T cell activation
