Innate and acquired activation pathways in T cells
Kenji Nakanishi
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. nakaken@hyo-med.ac.jp
Secretion of IFN- by T cells is usually the result of antigen stimulation. However, a newly identified GADD45 pathway can implement IFN- production after exposure to cytokines IL-18 and IL-12 without need of antigen.