Quiescent T cells: actively maintaining inactivity
Xianxin Hua
& Craig B. Thompson
Departments of Cancer Biology and Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. huax@mail.med.upenn.edu or drt@mail.med.upenn.edu
New evidence suggests that mediators of T cell quiescence and immune suppression converge on a common transcriptional program. Tob, a member of a family of anti-proliferation regulators, actively maintains T cell quiescence by interacting with components of the TGF- signal transduction pathway.
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signal transduction pathway.
