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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  2, 1091 - 1092 (2001) doi:10.1038/ni1201-1091 CD8+ T cell development: CD4 to the rescue H. Robson MacDonald & Werner Held Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland. hughrobson.macdonald@isrec.unil.ch or werner.held@isrec.unil.ch How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE Lymphoid Development Nature Encyclopaedia of Life Sciences  See all 3 matches for Reference REVIEWS T-cell development and the CD4-CD8 lineage decision Nature Reviews Immunology Review Article (01 May 2002)  See all 10 matches for Reviews NEWS AND VIEWS If at first you don't succeed Nature Immunology News and Views (01 Oct 2000) Deadbeat neighbors influence thymocyte lineage commitment Nature Immunology News and Views (01 Aug 2003)  See all 7 matches for News And Views RESEARCH Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment Nature Immunology Article (01 Dec 2001) Deletion of -catenin impairs T cell development Nature Immunology Article (01 Dec 2003)  See all 19 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... More Challenges Powered by: nature jobs Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation Syngene International Bangalore, Karnataka 560099 India Scientist / Sr. Scientist - Biopharmaceutics Syngene International Bangalore, Karnataka 560099 India More science jobs Post a job for free Figures & Tables See also: Article by Leung et al. Export citation Search buyers guide:   ADVERTISEMENT

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