Immunity or tolerance? That is the question for dendritic cells
Ken Shortman
& William R. Heath
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. shortman@wehi.edu.au
The "two-signal" model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.
