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Journal home Advance online publication Current issue Archive Press releases Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Immunology Nature Medicine Nature Cell Biology NI Tutorial: Finding regulatory DNA regions Signaling Gateway Immunology & Cell Biology Mucosal Immunology Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Immunology  2, 904 - 905 (2001) doi:10.1038/ni1001-904 The T Cell Receptor SLAPs Integrins Together Darren G. Woodside1, Sanford J. Shattil1, 2 & Mark H. Ginsberg1, 3 1  Department of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. 2  Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. 3  Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.ginsberg@scripps.edu Most receptors transmit extracellular signals to the cytoplasm, but integrins can also be stimulated in the reverse direction. A recent pair of Science papers report that "inside-out" signaling from the TCR is mediated by a newly identified protein called SLAP-130 or Fyb. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE Lymphocytes: Antigen-Induced Gene Activation Nature Encyclopaedia of Life Sciences REVIEWS The role of the adapter molecule SLP-76 in platelet function Oncogene Reviews (02 Oct 2001)  See all 12 matches for Reviews NEWS AND VIEWS Antigen receptors rap to integrin receptors Nature Immunology News and Views (01 Mar 2002) Vav and the B cell signalosome Nature Immunology News and Views (01 Jun 2001)  See all 3 matches for News And Views RESEARCH SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility The EMBO Journal Article (15 Dec 2000) Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor Oncogene Original Article (08 Mar 2001)  See all 21 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Optimizing Sub-cellular Localization Tags Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... More Challenges Powered by: nature jobs Scientist (Bioinformatics) Polyclone Bioservices Pvt. Ltd Bangalore India Senior Statistical Genetics in High-throughput Sequencing Analysis University of Oxford Oxford United Kingdom More science jobs Post a job for free Figures & Tables Export citation Search buyers guide:   ADVERTISEMENT

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