Can we apply the TH1-TH2 paradigm to all lymphocytes?
Marco Colonna
Basel Institute for Immunology, 487 Grenzacherstrasse, Basel, CH-4005, Switzerland.colonna@bii.ch
The TH1-TH2 paradigm, in which CD4+ T cells polarize into type 1 or type 2 helper cells, has been extended to other cells types. However, evidence now suggests that NK cells differentiate sequentially from immature type 2 to mature type 1 cells, a pathway that could apply to other lymphocytes.
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