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A rheostat tuning thymic selection

Nature Immunology volume 18, pages 713–714 (2017)Cite this article

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Thymocytes must undergo positive selection to survive and differentiate. This process is regulated by the TCR-sensitive protein CHMPS by preventing Bcl2 oxidation and degradation.

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Figure 1: TCR signaling alters post-translational regulation of CHMP5 to modulate double-positive CD4+CD8+ thymocyte survival.

Debbie Maizels/Springer Nature

References

  1. Adoro, S. et al. Nat. Immunol. 18, 780–790 (2017).

    Article  CAS  Google Scholar 

  2. Gascoigne, N.R., Rybakin, V., Acuto, O. & Brzostek, J. Annu. Rev. Cell Dev. Biol. 32, 327–348 (2016).

    Article  CAS  Google Scholar 

  3. Linette, G.P. et al. Immunity 1, 197–205 (1994).

    Article  CAS  Google Scholar 

  4. Bouillet, P. et al. Nature 415, 922–926 (2002).

    Article  CAS  Google Scholar 

  5. Villunger, A. et al. Proc. Natl. Acad. Sci. USA 101, 7052–7057 (2004).

    Article  CAS  Google Scholar 

  6. Henne, W.M., Buchkovich, N.J. & Emr, S.D. Dev. Cell 21, 77–91 (2011).

    Article  CAS  Google Scholar 

  7. Rusten, T.E., Vaccari, T. & Stenmark, H. Nat. Cell Biol. 14, 38–45 (2011).

    Article  Google Scholar 

  8. Shim, J.H. et al. J. Cell Biol. 172, 1045–1056 (2006).

    Article  CAS  Google Scholar 

  9. Greenblatt, M.B. et al. J. Exp. Med. 212, 1283–1301 (2015).

    Article  CAS  Google Scholar 

  10. Li, D., Ueta, E., Kimura, T., Yamamoto, T. & Osaki, T. Cancer Sci. 95, 644–650 (2004).

    Article  CAS  Google Scholar 

  11. Dufner, A. et al. Nat. Immunol. 16, 950–960 (2015).

    Article  CAS  Google Scholar 

  12. McCaughtry, T.M., Baldwin, T.A., Wilken, M.S. & Hogquist, K.A. J. Exp. Med. 205, 2575–2584 (2008).

    Article  CAS  Google Scholar 

  13. Metzger, T.C. & Anderson, M.S. Immunol. Rev. 241, 89–103 (2011).

    Article  CAS  Google Scholar 

  14. Walley, J.W. et al. Science 353, 814–818 (2016).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology of the University of California, San Diego, La Jolla, California, USA

    Gerald P Morris

  2. Departments of Molecular Biology and Cellular and Molecular Medicine of the University of California, San Diego, La Jolla, California, USA

    Stephen M Hedrick

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  1. Gerald P Morris
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  2. Stephen M Hedrick
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Correspondence to Gerald P Morris or Stephen M Hedrick.

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The authors declare no competing financial interests.

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Morris, G., Hedrick, S. A rheostat tuning thymic selection. Nat Immunol 18, 713–714 (2017). https://doi.org/10.1038/ni.3778

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