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Unusual suspects: dancing with stromal cells

M cells sample gut lumenal antigens and microbes to induce gut immune responses. A novel population of stromal cell—the M cell inducers—are essential for sustaining M cell differentiation and bacteria-specific production of immunoglobulin A to maintain the gut–immune system symbiosis.

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Figure 1: RANKL-mediated regulation of M cells by MCi cells in GALT.

Katie Vicari/Nature Publishing Group

References

  1. Nagashima, K. et al. Nat. Immunol. 18, 675–682 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Snippert, H.J. et al. Cell 143, 134–144 (2010).

    Article  CAS  Google Scholar 

  3. Golovkina, T.V., Shlomchik, M., Hannum, L. & Chervonsky, A. Science 286, 1965–1968 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Rios, D. et al. Mucosal Immunol. 9, 907–916 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Taylor, R.T. et al. J. Immunol. 178, 5659–5667 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Kanaya, T. et al. Nat. Immunol. 13, 729–736 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lum, L. et al. J. Biol. Chem. 274, 13613–13618 (1999).

    Article  CAS  Google Scholar 

  8. Yasuda, H. et al. Proc. Natl. Acad. Sci. USA 95, 3597–3602 (1998).

    Article  CAS  Google Scholar 

  9. Nakashima, T. et al. Biochem. Biophys. Res. Commun. 275, 768–775 (2000).

    Article  CAS  Google Scholar 

  10. Hikita, A. et al. J. Biol. Chem. 281, 36846–36855 (2006).

    Article  CAS  Google Scholar 

  11. Lai, W.T., Krishnappa, V. & Phinney, D.G. Stem Cells 29, 1102–1111 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hsieh, E.H. & Lo, D.D. Dev. Comp. Immunol. 37, 306–312 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Gabrielle T Belz.

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Belz, G., Almeida, F. Unusual suspects: dancing with stromal cells. Nat Immunol 18, 601–602 (2017). https://doi.org/10.1038/ni.3741

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