Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.
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Turner, M., Monzón-Casanova, E. RNA-binding proteins mind the GAPs. Nat Immunol 18, 146–148 (2017). https://doi.org/10.1038/ni.3662
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DOI: https://doi.org/10.1038/ni.3662
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