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IFN-λ 'guts' neutrophil-mediated inflammation

Nature Immunology volume 18, pages 1061–1062 (2017)Cite this article

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Interferon-λ (IFN-λ) curbs neutrophil-mediated intestinal inflammation by diminishing the production of reactive oxygen species and subsequent oxidative stress. This regulatory process is unique to IFN-λ and is independent of interferon-induced transcription and translation programs.

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Figure 1: IFN-λ produced in response to enteric viruses regulates intestinal inflammation via diminishing neutrophil function.

Kim Caesar/Springer Nature

References

  1. Kolaczkowska, E. & Kubes, P. Nat. Rev. Immunol. 13, 159–175 (2013).

    Article  CAS  Google Scholar 

  2. Broggi, A. Nat. Immunol. 18, 1084–1093 (2017).

    Article  CAS  Google Scholar 

  3. Trinchieri, G. J. Exp. Med. 207, 2053–2063 (2010).

    Article  CAS  Google Scholar 

  4. Kotenko, S.V. et al. Nat. Immunol. 4, 69–77 (2003).

    Article  CAS  Google Scholar 

  5. Sheppard, P. et al. Nat. Immunol. 4, 63–68 (2003).

    Article  CAS  Google Scholar 

  6. Sommereyns, C., Paul, S., Staeheli, P. & Michiels, T. PLoS Pathog. 4, e1000017 (2008).

    Article  Google Scholar 

  7. McFarland, A.P. et al. Nat. Immunol. 15, 72–79 (2014).

    Article  CAS  Google Scholar 

  8. Bolen, C.R., Ding, S., Robek, M.D. & Kleinstein, S.H. Hepatology 59, 1262–1272 (2014).

    Article  CAS  Google Scholar 

  9. Jilg, N. et al. Hepatology 59, 1250–1261 (2014).

    Article  CAS  Google Scholar 

  10. Davidson, S. et al. EMBO Mol. Med. 8, 1099–1112 (2016).

    Article  CAS  Google Scholar 

  11. Galani, I.E. et al. Immunity 46, 875–890 (2017).

    Article  CAS  Google Scholar 

  12. Blazek, K. et al. J. Exp. Med. 212, 845–853 (2015).

    Article  CAS  Google Scholar 

  13. Odendall, C. et al. Nat. Immunol. 15, 717–726 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Immunology, University of Washington, Seattle, Washington, USA

    Emily A Hemann, Johannes Schwerk & Ram Savan

Authors
  1. Emily A Hemann
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  2. Johannes Schwerk
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  3. Ram Savan
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Correspondence to Ram Savan.

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The authors declare no competing financial interests.

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Hemann, E., Schwerk, J. & Savan, R. IFN-λ 'guts' neutrophil-mediated inflammation. Nat Immunol 18, 1061–1062 (2017). https://doi.org/10.1038/ni.3834

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