A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.
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Korn, T. Disentangling the manifold functions of RORγt. Nat Immunol 18, 1059–1060 (2017). https://doi.org/10.1038/ni.3831
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DOI: https://doi.org/10.1038/ni.3831