Different cellular sources and signaling mechanisms mediate the effects of IL-6 on the generation of pathogenic TH17 helper T cells and the suppression of Foxp3+ regulatory T cells.
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Quintana, F. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol 18, 8–10 (2017). https://doi.org/10.1038/ni.3637
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DOI: https://doi.org/10.1038/ni.3637