The transcription factors Tcf1 and Lef1 have intrinsic histone-deacetylase activity that is required for the repression of CD4+ T cell–lineage genes in CD8+ T cells.
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Ng, C., Littman, D. Tcf1 and Lef1 pack their own HDAC. Nat Immunol 17, 615–616 (2016). https://doi.org/10.1038/ni.3469
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DOI: https://doi.org/10.1038/ni.3469
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