The silencing of autoreactive immature B cells is regulated by the binding of self antigens to B cell antigen receptors. New findings show that microRNAs control mechanisms of B cell tolerance.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Burnet, F.M. The Clonal Selection Theory of Acquired Immunity (The University Press: Cambridge, 1959).
Gonzales-Martin, A. et al. Nat. Immunol. 17, 433–440 (2016).
Lam, K.P., Kühn, R. & Rajewsky, K. Cell 90, 1073–1083 (1997).
Radic, M.Z. & Weigert, M. Ann. NY Acad. Sci. 764, 384–396 (1995).
Nemazee, D. Nat. Rev. Immunol. 6, 728–740 (2006).
Halverson, R., Torres, R.M. & Pelanda, R. Nat. Immunol. 5, 645–650 (2004).
Wardemann, H. et al. Science 301, 1374–1377 (2003).
Kinnunen, T. et al. Blood 121, 1595–1603 (2013).
Meffre, E. Ann. NY Acad. Sci. 1246, 1–10 (2011).
Edwards, J.C.W. et al. N. Engl. J. Med. 350, 2572–2581 (2004).
Hauser, S.L. et al.; HERMES Trial Group. N. Engl. J. Med. 358, 676–688 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Meffre, E. Big impact of microRNAs on central B cell tolerance. Nat Immunol 17, 353–354 (2016). https://doi.org/10.1038/ni.3414
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3414
