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Glycolysis and EZH2 boost T cell weaponry against tumors

Nature Immunology volume 17, pages 41–42 (2016)Cite this article

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Low availability of glucose in tumors negatively affects the activity of tumor-infiltrating T cells. Loss of T cell function under these conditions is mediated by the microRNAs miR-101 and miR-26a, which target expression of the methytransferase EZH2 and thereby diminish the expression of anti-tumor cytokines.

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Figure 1: The effect of glucose restriction on the function of tumor infiltrating lymphocytes.

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Authors and Affiliations

  1. Glenn R. Bantug and Christoph Hess are in the Department of Biomedicine, University of Basel, Basel, Switzerland.,

    Glenn R Bantug & Christoph Hess

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  1. Glenn R Bantug
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  2. Christoph Hess
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Correspondence to Christoph Hess.

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Bantug, G., Hess, C. Glycolysis and EZH2 boost T cell weaponry against tumors. Nat Immunol 17, 41–42 (2016). https://doi.org/10.1038/ni.3346

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