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A vision and a prescription for big data–enabled medicine

Nature Immunology volume 16, pages 435–439 (2015)Cite this article

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Genetic, environmental and socioeconomic factors render humanity remarkably diverse. '-Omic' and sensor technologies permit the capture of this diversity with unprecedented precision. Leveraging these technologies in clinical decision making will help to bring about the long-heralded personalization of medicine.

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Figure 1: Capturing individual variation with the help of mobile-sensor and molecular-profiling technologies in the era of big data–enabled medicine.
Figure 2: Windows of opportunity afforded by high-resolution proximity testing.

References

  1. Medawar, P. in The Reith Lectures (BBC Radio 4, 1959).

    Google Scholar 

  2. Pulendran, B. Proc. Natl. Acad. Sci. USA 111, 12300–12306 (2014).

    Article  CAS  Google Scholar 

  3. Chatterjee, B. & Pancholi, J. Ayu 32, 141–146 (2011).

    Article  Google Scholar 

  4. Bennett, L. et al. J. Exp. Med. 197, 711–723 (2003).

    Article  CAS  Google Scholar 

  5. Griffiths, M.J. et al. J. Infect. Dis. 191, 1599–1611 (2005).

    Article  CAS  Google Scholar 

  6. Mejias, A. et al. PLoS Med. 10, e1001549 (2013).

    Article  Google Scholar 

  7. Moal, V. et al. J. Infect. Dis. 207, 125–132 (2013).

    Article  CAS  Google Scholar 

  8. Mostafavi, S. et al. Mol. Psychiatry 19, 1267–1274 (2014).

    Article  CAS  Google Scholar 

  9. Smih, F. et al. PLoS ONE 6, e20414 (2011).

    Article  CAS  Google Scholar 

  10. Stamova, B. et al. Stroke 41, 2171–2177 (2010).

    Article  Google Scholar 

  11. Li, S. et al. Nat. Immunol. 15, 195–204 (2014).

    Article  Google Scholar 

  12. Obermoser, G. et al. Immunity 38, 831–844 (2013).

    Article  CAS  Google Scholar 

  13. Gaucher, D. et al. J. Exp. Med. 205, 3119–3131 (2008).

    Article  CAS  Google Scholar 

  14. Querec, T.D. et al. Nat. Immunol. 10, 116–125 (2009).

    Article  CAS  Google Scholar 

  15. Oswald, M. et al. Arthritis Rheumatol. 67, 344–351 (2014).

    Article  Google Scholar 

  16. Hecker, M. et al. Mol. Neurobiol. 48, 737–756 (2013).

    Article  CAS  Google Scholar 

  17. Novershtern, N. et al. Cell 144, 296–309 (2011).

    Article  CAS  Google Scholar 

  18. Pascual, V. et al. Immunol. Rev. 223, 39–59 (2008).

    Article  CAS  Google Scholar 

  19. Panelli, M.C. et al. Genome Biol. 3, research0035.1–research0035.17 (2002).

    Article  Google Scholar 

  20. Berry, M.P. et al. Nature 466, 973–977 (2010).

    Article  CAS  Google Scholar 

  21. Martínez-Llordella, M. et al. J. Clin. Invest. 118, 2845–2857 (2008).

    PubMed  PubMed Central  Google Scholar 

  22. Newell, K.A. et al. J. Clin. Invest. 120, 1836–1847 (2010).

    Article  CAS  Google Scholar 

  23. Chiche, L. et al. Arthritis Rheumatol. 66, 1583–1595 (2014).

    Article  CAS  Google Scholar 

  24. Brenner, S. Philos. Trans. R. Soc. Lond. B Biol. Sci. 365, 207–212 (2010).

    Article  Google Scholar 

  25. Ertin, E. et al. in Proc. 9th Int. Conf. Embedded Networked Sensor Systems (SenSys) (ACM, 2011).

    Google Scholar 

  26. Rahman, T. et al. in Proc. Int. Conf. Mobile Systems, Applications, Services (MobiSys) (ACM, 2014).

    Google Scholar 

  27. Nikzad, N. et al. in Proc. Conf. Wireless Health (WH '12) (ACM, 2012).

    Google Scholar 

  28. Chaussabel, D. & Baldwin, N. Nat. Rev. Immunol. 14, 271–280 (2014).

    Article  CAS  Google Scholar 

  29. Kaizer, E.C. et al. J. Clin. Endocrinol. Metab. 92, 3705–3711 (2007).

    Article  CAS  Google Scholar 

  30. Woods, C.W. et al. PLoS ONE 8, e52198 (2013).

    Article  CAS  Google Scholar 

  31. Lukaszewski, R.A. et al. Clin. Vaccine Immunol. 15, 1089–1094 (2008).

    Article  CAS  Google Scholar 

  32. Kallionpää, H. et al. Diabetes 63, 2402–2414 (2014).

    Article  Google Scholar 

  33. Ockenhouse, C.F. et al. Infect. Immun. 74, 5561–5573 (2006).

    Article  CAS  Google Scholar 

  34. Quick, J., Quinlan, A.R. & Loman, N.J. Gigascience 3, 22 (2014).

    Article  Google Scholar 

  35. Chaussabel, D. et al. Immunity 29, 150–164 (2008).

    Article  CAS  Google Scholar 

  36. Nakaya, H.I. et al. Nat. Immunol. 12, 786–795 (2011).

    Article  CAS  Google Scholar 

  37. Oh, J.Z. et al. Immunity 41, 478–492 (2014).

    Article  CAS  Google Scholar 

  38. Ravindran, R. et al. Science 343, 313–317 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Damien Chaussabel is at the Sidra Medical and Research Center, Doha, Qatar.,

    Damien Chaussabel

  2. Bali Pulendran is at the Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.,

    Bali Pulendran

Authors
  1. Damien Chaussabel
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  2. Bali Pulendran
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Correspondence to Damien Chaussabel or Bali Pulendran.

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The authors declare no competing financial interests.

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Chaussabel, D., Pulendran, B. A vision and a prescription for big data–enabled medicine. Nat Immunol 16, 435–439 (2015). https://doi.org/10.1038/ni.3151

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