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To κ+ B or not to κ+ B

Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain+ B cell development.

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Figure 1: Brwd1 stimulates the accessibility and recombination of Igk.

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Correspondence to Craig H Bassing.

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C.H.B. is a consultant for Regeneron Pharmaceuticals.

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Fisher, M., Bassing, C. To κ+ B or not to κ+ B. Nat Immunol 16, 1007–1009 (2015). https://doi.org/10.1038/ni.3277

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